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MOTS-c is encoded in the mitochondrial genome itself, which is why it is studied as part of a distinct signalling class mitochondrial-derived peptides rather than alongside conventional nuclear-encoded peptides
Timing-dependent effects primarily influence circadian phase alignment, sleepwake timing, and synchronization between central and peripheral clocks, whereas dose-dependent effects are more closely related to signal amplitude, antioxidant capacity, and cytoprotective actions
Duffy et al., 2011
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