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This metabolic dysregulation is defined by systemically reduced levels of metabolites such as amino acids and fatty acids, leading to reduced TCA cycle activity and oxidative phosphorylation, which may ultimately be a major contributor to neuropsychiatric symptoms associated with reduced energy, such as fatigue and other cognitive impairments [43, 62]

Journal of Biological Chemistry, 250 (4), 14221426

Its important to consult a healthcare provider to determine the appropriate semaglutide dose and to gradually adjust the dose to help minimize side effects like fatigue

The injectable pen comes in the same dose strengths available in the United States: 0.25 mg, 0.5 mg, 1 mg, and 2 mg

Int J Mol Sci 22(4):1619