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It acts as a non-selective melanocortin receptor agonist with the following binding profile (approximate Ki values): MC1R : ~0.67 nM (highest affinity, melanogenesis) MC4R : ~6.6 nM (appetite suppression, sexual function) MC3R : ~34 nM (energy balance) MC5R : ~46 nM (exocrine gland function) This broad receptor profile produces multiple physiological effects
Chandra D, Gupta SS
They also offer renal protection and have been shown to reduce the risk of heart failure hospitalizations and cardiovascular events in patients with diabetes.
10.1016/j.colsurfb.2022.112999 103 TfilinM.GobshtisN.FozailoffD.FraifeldV
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