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When you are eating far less, it is easy to skip the vegetables and fruit that keep digestion moving, which is how constipation creeps in

Trends Pharmacol Sci 20:302309

It remains a research compound in most jurisdictions, available for purchase as a research chemical but not as a regulated medication

Long-term safety: Published human studies extend to 12 weeks maximum

We were exploring ways of developing peptides that bind selectively, and we were very successful at that, but then we confronted the problem that our short, 23-residue peptides are not promising therapeutic candidates primarily because they cannot get into cells, Keating says