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Time Window (Start and End Dates): The search included studies published from the database inception to July 2025
As policymakers debate coverage, clinicians weigh long-term strategies, and society argues over who deserves access, the voices in this study are a reminder that the story of GLP-1 medications was never only about weight loss as much as it is about agency
Additionally, in the OASIS 1 trial (19), oral semaglutide at a dose of 50 mg, which is not yet available for clinical use in obesity or type 2 diabetes, induced an average of 15% weight loss, with 85% of participants achieving at least 5% weight loss (compared to 26% with placebo) and 54% achieving at least 15% weight loss
The results of long COVID investigations cautiously suggest that impaired metabolism and neuronal dysfunction may play a role in mental fatigue, similar to hypotheses for ME/CFS
"GLP-1s are beautiful tools when used in the right way for the right patient, but not everyone is the right patient," Dr
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