papillary thyroid cancer semaglutide GLP-1RA and cancer: New study suggests detection bias, not causation Frontiers | Glucagon-like peptide-1 receptor

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Those with unstable psychiatric conditions or active substance use disorders require careful evaluation before starting appetite modifying medications

In the SOUL trial (Semaglutide cardiOvascular oUtcomes trial) just published in May 2025, 9650 participants 50 years of age or older who had T2D with a HbA1c of 6.5 to 10.0%, and had known atherosclerotic cardiovascular disease, chronic kidney disease, or both to receive either once-daily oral semaglutide (maximal dose, 14 mg) or placebo, in addition to standard care (5)

In general a Cohen's d effect size between 0.2 and 0.4 is small, between 0.5 and 0.7 is medium and 0.8 or above is large

Here's what the FDA reclassification means for peptide researchers