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Biallelic variants in UBA5 link dysfunctional UFM1 ubiquitin-like modifier pathway to severe infantile-onset encephalopathy
MD simulations Initial wild-type GLP-1R model for MD simulations was obtained from the GLP-1R-Fab7F38 structure with modifications: (1) antibody (Fab7F38) and fusion protein (rubredoxin) were removed
What breaks them
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Thus, the CREDENCE trial showed canagliflozin to be superior to placebo in individuals with type 2 diabetes who had albuminuria and a range of renal function using a primary composite endpoint composed of end-stage renal disease, doubling of serum creatinine and death from renal or CV cause (Perkovic et al, 2019)
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