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The first study I could find using DSIP for treating withdrawal symptoms was published in 1983: DSIP (25 nmol/kg) was injected intravenously as sole treatment to 67 patients presenting withdrawal symptoms (28 from ethyl alcohol, 39 from opiates)

They reduce inflammation and oxidative stress , both of which impact muscle retention

This is probably one of the reasons why Centella Asiatica Extract has nice skin moisturizing properties that was confirmed by a 25 people, four weeks study along with Centella's anti-inflammatory effects

(5) Follow-up duration