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As an add-on to background therapy, semaglutide demonstrated superiority to placebo in PIONEER 8 (semaglutide 3 mg, 7 mg, and 14 mg), PIONEER 4 (14 mg only), and in patients with renal impairment in PIONEER 5 (14 mg only)
The mechanisms operate in entirely separate biological pathways
is not a weight loss drug
Nausea affects 30% to 44% of people, diarrhea occurs in about 30%, constipation affects 24% to 28%, and vomiting happens in 9% to 15%
Type 2 diabetes is the most common form of diabetes in which the body makes or uses insulin in an abnormal way, resulting in higher blood glucose levels
![Physiologic effects of GLP-1 (adapted from Granata et al. [11])](https://www.researchgate.net/publication/359199250/figure/fig1/AS:11431281081130351@1661532031197/Physiologic-effects-of-GLP-1-adapted-from-Granata-et-al-11.png)
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