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Patients deserve a clear plan, not a product-driven protocol
Translation to humans remains uncertain due to physiological differences
Occasional minor irritation during adaptation is normal, but ongoing redness, sensitivity, or discomfort indicates problems
However, in the real world this isnt always possible
Exendin-4 significantly increased insulin level and phosphorylation of insulin receptor substrate 1 (IRS-1) in rat hippocampus, and could not change the status of tau phosphorylation without insulin in HT22 neurons, suggesting that insulin is required in reduction of tau hyperphosphorylation by GLP-1R agonists (154)
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