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In such situations, effective contraception should be used [seeWarnings and Precautions (5.2, 5.3, 5.4)]

However, Compound 12 was unfortunately identified as a substrate of multidrug resistance protein 1 (MDR1, P-gp) in MadinDarby canine kidney (MDCK) cells with an efflux ratio greater than 5, which precluded its development as a candidate for CNS drugs

Another common preclinical model involves using chemically induced damage, such as oxidative stress or inflammation, to test the peptides potential in mitigating cellular damage

Its primary function is to help transport fatty acids into the mitochondria, where they can be converted into energy

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