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Although this study involved a single intratracheal instillation and fibrosis gradually improved during the chronic phase, this temporal pattern parallels observations in other models of acute lung injury, such as bleomycin- or LPS-induced injury, as well as in clinical cases of ARDS, where acute inflammation subsides but fibrotic pathways remain active and remodeling continues 32,33,34
The goal of the protocol: Recovery, soft tissue repair, tendon support, and maintenance may all involve different approaches
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This functional loss was exacerbated in mice lacking IGF-1R in other retinal cells, including rod photoreceptor cells
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