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In beta cell mitochondria, ROS produced during oxidative phosphorylation are detoxified by the glutathione redox system, which requires NADPH to maintain its redox state [92]
Reduced GSH is deployed through two enzyme families: glutathione peroxidases ( GPX1-8 ) that use GSH to neutralize hydrogen peroxide and lipid hydroperoxides (producing GSSG), and glutathione S-transferases ( GSTM1, GSTT1, GSTP1 ) that conjugate electrophilic xenobiotics and endogenous reactive species to GSH for excretion
That takes randomized, controlled clinical trials
GLP1 medications do more than support weight lossthey can play a meaningful role in heart health, blood sugar control and even sleep quality
The drugs benefits are clear, but their vast benefits could also be a double-edged sword
