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The activation of TFEB requires modification of a specific lysine residue in the translation initiation factor 5A (eIF-5A) generating what is called hypusine (derived from hy droxy pu trescine and ly sine ) which involves spermidine as outlined in the Polyamines in Protein Modification below
References 1 AgishaV
Shima S, Mizutani Y, Yoshimoto J, Maeda Y, Ohdake R, Nagao R, et al
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