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[7] [12] However, Phase 2 trials are not powered to detect rare cardiovascular outcomes, and longer-term Phase 3 data including dedicated cardiovascular outcome trials will be essential to fully characterise the cardiac safety profile of retatrutide

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Beyond these classical metabolites, elevated L-tryptophan levels can also promote GLP-1 secretion in mouse intestinal L cells and contribute to -cell regeneration in db/db mice

FSP1, another well-known suppressor of ferroptosis, acts independently of the ACSL4/GPX4 pathway

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