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Finally, the mice were tested the CCK-injected food intake for SDV validation
Ceriello A, Novials A, Ortega E, et al
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This resistance occurs through the cAMP-EPAC-RAP1 signaling pathway, which significantly reduces leptin-induced appetite suppression and subsequent weight loss [100,101,102,103]
In one trial, the condition occurred in 4% of those on Wegovy who had type 2 diabetes and overweight compared to 2.7% of the placebo group
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