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This sample was analyzed using the reversed-phase liquid chromatography (RPLC) platform in negative electrospray ionization mode (for detection of ribose-5-phosphate, citrate, succinate, fumarate, and lactate)

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As the metabolic landscape is highly variable across patients and tumors (254256), future clinical trials should attempt to incorporate metabolic profiling to determine whether specific metabolic phenotypes correlate with improved outcomes of combination therapies