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Efruxifermin (formerly AKR-001, AMG 876), the only other FGF21 analog studied in a clinical trial of biopsy-confirmed NASH patients, is a 92 kDa Fc-FGF21fusion protein with a 33.5 day half-life (based on intact C-terminal domain of the FGF21 moiety), which is substantially extended relative to the FGF21 analogs described above

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Contraindications include personal or family history of medullary thyroid carcinoma or MEN 2 syndrome, pancreatitis history, severe GI or kidney disease, pregnancy, and breastfeeding

Hasanuzzaman, M., Nahar, K., Anee, T