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For the master trial focusing on obesity or overweight, 2,339 eligible adults who had at least one weight-related comorbidity but without diabetes were randomised in a 1:1:1:1 ratio to receive retatrutide in doses of 4 mg, 9 mg, 12 mg, or a placebo

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doi: 10.1186/s12974-023-02856-0 229 YuH.WanX.YangM.XieJ.XuK.WangJ.et al

This evidence-based review provides a comprehensive overview of the GLP-1 receptor agonist class, comparing their mechanisms, indications, pharmacokinetics, and efficacy, and summarizes safety data and guideline recommendations

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