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As per William E

After supplementing with glutathione for 12 weeks while participating in a randomized, double-blind, placebo-controlled trial, healthy female subjects reported improved skin elasticity and fewer wrinkles

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Poor Nutrition: A diet lacking in the amino acids and minerals (like selenium) needed to create glutathione can hamper natural production

One hypothesis is that we observed a greater induction of NRF2 through liver-specific Gclc deletion as compared to KEAP1 inhibition with CDDO-me because CDDO-me is a weaker inhibitor of NRF2-KEAP1 interaction compared to the ROS generated following GSH depletion