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Dual-pathway GH stimulation: in published endocrinology research, GHRH-receptor agonism (CJC-1295) and ghrelin-receptor agonism (ipamorelin) act through complementary intracellular pathways, with the combination producing larger GH pulses than either alone in animal model and isolated pituitary cell research

This combination is of interest to researchers because the three pathways influence insulin secretion, energy expenditure, and hepatic lipid handling through partly distinct routes, making the compound a useful tool for dissecting how multi-receptor signalling differs from single- or dual-pathway models studied to date

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The recently reported positive cell sorting system utilizes GPI-anchored Twin-Strep-Tag as the affinity tag and allows the positive cells to be enriched with Strep-Tactin magnetic beads (Yang et al., 2022)

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