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Shigeoka, T., Nomiyama, T., Kawanami, T., Hamaguchi, Y., Horikawa, T., Tanaka, T., Irie, S., Motonaga, R., Hamanoue, N., Tanabe, M., et al
But theres no data showing how well it works in humans, and the long-term safety of this peptide in humans is simply unknown
The adverse events associated with GLP-1 RA use are generally mild and include nausea and vomiting
Due to the lack of oxidation, the fatty acids accumulate in the liver, skeletal muscle, and heart resulting in hepatic steatosis, myopathy, and cardiomyopathy, respectively
Interestingly, in echidna GLP-1 there is less conservation of the receptor binding residues with additional changes at the N-terminal receptor binding Phe 12 (conservatively substituted to Tyr) and Asp 15 (changed to Glu) residues
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