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The two reasons are that CBS is activated by estradiol and betaine (Bet), which is twice as high in females compared to males because the enzyme PEMT [Figure 1] is activated by a factor of 2.3 in menstruating females
Most standard supplements do not directly interact with GLP-1 receptor agonists
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Theyre part of a whole lineup of drugs that can help you lose weight, including some that have been around for decades (or in one case, since 1959!)
The problem: very short half-life (~50 minutes) and 3 daily injections at meals , an extremely impractical regimen
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