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3.2.3 Individual differences in metabolic regulation While the metabolic routes of Omega-3 fatty acids are multifaceted, they can be disrupted by both genetic and environmental influences, so that their regulatory mechanisms vary from individual to individual, mainly in two aspects, one is genetic factors, FADS1/2 gene polymorphisms affect the conversion efficiency of Omega-3 fatty acids to long-chain fatty acids, and some people need to directly supplement DHA/EPA (65)

doi: 10.1093/cvr/cvac013 62 MarguliesKBHernandezAFRedfieldMMGivertzMMOliveiraGHColeRet al

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