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Thus, Htt reduces Cu 2+ to Cu 1+ , and copper promotes its aggregation, mediated by histidine residues ( Figure 6 schematizes the pathways that lead to symptoms of Huntingtons disease as a consequence of misfolded mutant Htt
This demonstrates a cognitive regulation of satiation, in which a feed-forward mechanism increases satiation before the initiation of a meal, eventually leading to meal termination (Fig
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