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Deleterious Effects of Astrocytes on Remyelination A transcriptomic analysis of astrocytes activated by different types of insults (ischemia, LPS injection) revealed that two types of reactive astrocytes could be distinguished: A1 astrocytes with detrimental effects on cell survival and regeneration and A2 astrocytes presenting protective effects (Zamanian et al., 2012)
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In contrast, a GSSR intermediate was detected and its decreased steady-state concentration at higher glutaredoxin concentrations was suggested to support monothiol mechanism (i) 60
These short chains amino acids function as signaling molecules, receptor ligands, and enzymatic modulators depending on their sequence and three-dimensional structure
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