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Building on seminal work from Firestein (1517) and Straub (8688), who postulated the CNS as a potential target for the treatment of rheumatic diseases, we experimentally confirmed their previous observations of reduced c-Fos protein expression and p38 phosphorylation locally in the spinal cord after intrathecal application of p38 or TNF- inhibitors, simply by oral histamine supplementation
This protective mechanism prevents pregnancy during perceived energy scarcity
More et al., 2017
Alcohol is calorie-dense and impairs the GLP-1 appetite signal
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