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The PAB model was surgically created by placing a constrictive band around the pulmonary artery (PA) to induce pressure overload

Neuen BL, Heerspink HJL, Vart P, Claggett BL, Fletcher RA, Arnott C, et al

The authors of this study noted that the pancreatic islets clearly benefited from Y1-R activation regardless of the diabetes status of the host 21

Pregnant or breastfeeding individuals There isnt enough human data to confirm astaxanthins safety during pregnancy or breastfeeding, so most experts recommend avoiding supplementation during these periods