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reported a similar astrocyte response, showing increased GFAP expression in the PL-PFC but not in the IL-PFC subdivision, after alcohol withdrawal (Bull et al., 2015)
Injury location: Areas with better blood supply typically heal faster than poorly vascularized tissues
Note that 2-PAM has an affinity for the acetylcholine anionic binding site on cholinesterase (right middle panel), which could explain the oxime related worsening of cholinergic side effects when 2-PAM is administered prior to the onset of action of atropine in the setting of organophosphate poisoning, by transiently preventing nerve-agent free cholinesterase from interacting with acetylcholine
Beyond the enzymes, the reported effects concentrate on extracellular-matrix gene expression
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