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The topical route is the format with the strongest human clinical trial evidence for skin outcomes, from the landmark 1998 Abdulghani study that outperformed both vitamin C and tretinoin to the Finkley skin-thickness data
Vitamin B12 is a complex vitamin that is water soluble
It does not contain any harsh chemicals that can irritate the skin, and it is gentle enough to be used daily
10.1007/s10695-012-9722-1 16 ChernorudskiyA.VaroneE.ColomboS.FumagalliS.CagnottoA.CattaneoA.et al (2020)
GHK-Cu stimulates the production of dermatan sulfate and glycosaminoglycans that hydrate and plump the dermal matrix, measurably improving skin thickness and density over treatment courses
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