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Semaglutide is known for its dual action on both reducing appetite and enhancing insulin sensitivity
This drug resistance can be triggered by the genomic instability that leads to tumor heterogeneity, involved in cancer progression
It was first discovered in human plasma and has since been found in saliva and urine
Of note, the prevalence of HF varied across these trials from 9% to 24%, and HF events were considered a secondary endpoint
For a fuller discussion of the asymptomatic gallstone question, see our dedicated page on asymptomatic gallstones
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