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The fourth is combination therapy
Although lifestyle changes are the first line of treatment for obesity, even the most rigorous lifestyle changes typically only produce a 510% weight loss and maintaining weight over time is difficult due to compensatory physiological processes that increase appetite and decrease energy expenditure [134]
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Pharmacokinetics of NNC0090-2746 showed a C max at 5.4 nM with a single dose of 1.8 mg (106) and C max at 12 nM at the steady state with a daily dose of 2 mg in patients with T2DM (107)
Second, neurodegenerative indications highlight a similar gap between mechanistic promise and clinical outcomes
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