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Given that glandular secretion in response to SubP is defective in CF, a speculation is that SubP-mediated secretion in CF might be associated with enhanced muc5AC to muc5B secretion ratios, effectively mimicking asthma [98]

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It will come down to developing a strategy, then choosing what we think are the right targets, designing stable molecules, running the studies, and having the discipline to stop if its not working