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Cardiovascular considerations : Severe caloric restriction can have adverse cardiac effects, including arrhythmias related to electrolyte disturbances
However, folic acid does not prevent neurological symptoms, and without proper treatment with vitamin B12, irreversible damage may occur
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Both are acceptable
4 A 2025 mechanistic study using RAMP1/RAMP3 knockout mice demonstrated this dependence directly: cagrilintide activated area postrema neurons and reduced body weight in wild-type animals but had essentially no effect in mice lacking these receptors, pinning its action to the AMY and AMY subtypes in the hindbrain
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