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ITTs were performed in random-fed mice, early in their light cycle (~0700h0800h) 46

Their functional plasticity, shifting between inflammatory, repair, or anti-inflammatory states, depends on metabolic adaptation and lipid remodeling, including choline uptake and phospholipid reorganization ( 2.1.1 Macrophages and dendritic cells Macrophage functions, such as cytokine and chemokine secretion, phagocytosis, and organelle biogenesis, are intricately linked to membrane phospholipid composition, curvature, and charge ( Figure 3 )

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The key differences come down to absorption rate, plasma concentration, and time to results

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