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However, treatment with APR-246 resulted in a clear decrease in the amount of free thiols in mutant p53-carrying Saos-2-His-273 cells, as the amount of fully reduced thiols was decreased from 76.3% to 17.0%, and as the amount of Trx1 without any free thiols (SH-0) increased with 8%, We obtained similar results for Trx2, where almost 50% of Trx2 in Saos-2 cells was in the fully reduced form and 63% in Saos-2-His-273 cells (Fig

As demonstrated by oxyntomodulin, a weak endogenous agonist for GLP-1 receptor and glucagon receptor, a strategy that simultaneously stimulates both GLP-1 and glucagon receptors can reduce food intake while increasing energy expenditure, synergistically enhancing weight loss [105-107]

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Douros, M.B