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Measurement of serum methylmalonic acid should be used to confirm deficiency in asymptomatic high-risk patients with low-normal levels of vitamin B 12
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Neuropathological findings in penicillamine-treated patients with Wilsons disease
Importantly this was based on two preclinical efficacy studies in the SOD1 G93A mouse which did not account for the now well described pitfalls in experimental design 10 , which have led to new guidelines for preclinical research
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