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p53 deficiency in AgRP neurons significantly induces an obese phenotype characterized by mild hyperphagia, elevated adiposity, and decreased energy expenditure under conditions of excess nutrition
Struggling with stubborn fat that just wont budge despite a healthy lifestyle
Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation
Shalev et al., 2000
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