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Its long-term effect makes it possible to observe a gradual change over time, giving information about the immediate and the long-term metabolic reactions
In individuals with type 2 diabetes, liraglutide decreased CNS activation after short- but not long-term intervention, suggesting that these effects of GLP-1 RA on the CNS may contribute to the induction of weight loss [44]
Second, GLP-1 receptor agonists have well-documented anti-inflammatory effects
Understanding the different risk profiles of GLP-1 RAs helps clinicians make informed treatment decisions by balancing therapeutic benefits with potential side effects
Among all randomized patients, patients who continued to receive SC semaglutide 2.4 mg for 48 weeks, the average weight continued to decrease by 7.9% from the baseline at randomization (weight at the end of the induction period)
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