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The Cochrane RoB 2 has seven study domains, including random sequence generation, allocation concealment, blinding of the investigators and participants, blinding of the outcome assessors, incomplete outcome data, selective outcome reporting, and other sources of bias

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Unlike FDA-approved medicationswhich include GLP-1 receptor agonists (semaglutide, liraglutide) and the dual GIP/GLP-1 receptor agonist tirzepatideprobiotic supplements are classified as dietary supplements under the Dietary Supplement Health and Education Act (DSHEA)