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doi:10.1124/pr.115.010629

Orthostatic blood pressure testing at the first combined dose remains the single most informative safety check: a systolic drop exceeding 20 mmHg or any symptomatic lightheadedness on standing should halt dose escalation and prompt clinical reassessment

A: It may help some people stay consistent with movement if discomfort or recovery were limiting, but it doesn't provide predictable weight loss by itself