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This was partly contributed by the relatively higher discontinuation rate observed in the EXSCEL trial [55], which studied once-weekly exenatide on cardiovascular outcomes in T2DM, given that the study did not have a run-in period to optimize medication adherence

Administration of L-N G -Nitroarginine Methyl Ester (L-NAME) attenuated this protective effect in mouse model [71], pointing to GLP-1-mediated cardioprotection through modulation of nitric oxides

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