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By binding copper(II) ions, it helps regulate gene expression linked to collagen formation, angiogenesis, antioxidant defense, and tissue remodeling. The peptides small size allows it to penetrate tissues efficiently, and its copper-transfer activity underlies its reported effects on skin, hair, and wound-healing processes in laboratory models

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The change in protonation state occurs at pH 9.47

Phull AR, Nasir B, Haq IU, Kim SJ

This can lead to systemic inflammation and a range of symptoms, including fatigue, brain fog, headaches, joint pain, bloating, gas, and diarrhea