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doi:10.1001/jamaoto.2025.4181 Medical News in Brief, GLP-1 Drugs Linked with Chronic Cough, JAMA, Published Online: December 19, 2025 doi: 10.1001/jama.2025.20026 Kobina Essilfie-Quaye et al, Semaglutide-Induced Silent Aspiration: An Unrecognised Cause of Organising Pneumonia, Respiratory Case Reports, Volume 13, Issue 7, July 2025, e70249, Avraham SA et al, Pulmonary aspiration of gastric contents in two patients taking semaglutide for weight loss
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Within the structure, TT-OAD2 protrudes beyond the receptor core to interact with the lipid or detergent, providing an explanation for the distinct activation kinetics that may contribute to the clinical efficacy of this compound series
This was corroborated by a marked effect on cAMP signaling in -arrestin-less HEK293 cells, which progressively diverged with longer exendin-4 treatment, reminiscent of the effect of exendin-phe1 on beta cell cAMP production
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