These observations disclose a combined mechanism that uses conserved residues for ligand recognition and specific barcodes to accommodate conformations unique to each receptor, leading to a highly potent and balanced unimolecular triple agonist for GIPR, GLP-1R and GCGR 14 with a cAMP signaling potency similar to that of GIP, GLP-1 and GCG (Fig
It is studied in research into body weight regulation, fat metabolism, appetite regulation and glucose metabolism, thanks to its activity at the GLP-1, GIP and glucagon receptor
It addresses the most common side effects nausea, fatigue, GI distress, and electrolyte depletion through targeted ingredients: electrolytes with B6 for nausea and hydration, B-Complex for GI support, and protein with whey isolate and digestive enzymes for muscle preservation and comfortable digestion
Do not push yourself to eat large meals
10.1016/j.cell.2016.05.023 108 WyshamC.BlevinsT.ArakakiR.ColonG.GarciaP.AtissoC.et al (2014)