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Key Phase 3 trials (TRIUMPH-1, -2, -3) are expected to read out by Q4 2026, with NDA submission projected for Q4 2026 to Q1 2027 and a PDUFA target action date of September to October 2027
Other causes include strict vegan diets, malabsorption disorders (coeliac disease, Crohn's disease), gastrointestinal surgery, and long-term use of medications such as metformin or proton pump inhibitors
MASLD Substudy Sanyal et al., Nature Medicine (2024) Sanyal and colleagues conducted a prespecified phase 2a substudy of the original phase 2 obesity trial, evaluating retatrutide in participants with metabolic dysfunction-associated steatotic liver disease (MASLD)
Mounjaro, en cambio, combina la accin sobre los receptores GLP-1 y GIP
Nutritional Support and Hydration During Tirzepatide Therapy GLP-1 medications like tirzepatide can reduce appetite so significantly that some patients unintentionally under-eat or become dehydratedboth of which increase diverticulitis risk
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