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Importantly, GLP-1RAs are able to improve -cell sensitivity to glucose and have the ability to improve the glycaemic profile indirectly by delaying gastric emptying, inhibiting hepatic glucose production and suppressing appetite, thereby promoting weight loss [9,10,11]

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Statistical analyses The efficacy analysis set (i.e., randomized and treated participants, excluding off-treatment data) using the efficacy estimand was used for this analysis

Last updated 10/2025

The research behind these compounds is limited, often small-scale or animal-based, and the real-world impact on GLP-1 and weight loss is modest at best