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Digestive Health: GLP-1s Impact on Gut Microbiota Gut health relies on a mixture of bacteria, fungi, viruses, and other microorganisms living in your digestive tract that are unique to you

Common side effects include: Nausea Constipation Vomiting Diarrhea Reflux Fatigue Headaches Nausea and constipation tend to improve as patients get used to taking the medication

Source: Healthline first month on GLP-1s Healthline's first-month GLP-1 guide notes that GLP-1 medications may reduce thirst and that nausea, vomiting, and diarrhea can increase dehydration risk

Metabolism: Absolutely

Tirzepatide became the first dual GLP/GLP-1 receptor agonist to gain FDA approval for treating T2DM in 2022 and obesity in 2023 [ Table 2 ]