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The positive impact of GLP-1RA therapy on lipids is an important contributor to these outcomes

Given the relatively smaller reduction in body weight (9.4%) in the SELECT trial compared to previous RCTs: 14.9% in STEP1 (BMI 37.86.7 kg/m 2 ) [16] and 13.2% STEP6 (BMI 31.9 kg/m 2 ) [49], pleiotropic effects of semaglutide may contribute to the overall CV risk reduction [25,37]

FDA Clarifies Policies for Compounders as National GLP-1 Supply Begins to Stabilize

A rigorous 2018 double-blind, placebo-controlled trial by Koozehchian et al

However, to achieve the therapeutic benefits of supplementation, as with other supplements, consistency is key to truly observe the benefits and results