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This dehydration can cause kidney problems, sometimes requiring hemodialysis
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Retatrutide has shown the highest weight loss numbers in trials so far (28.7% in Phase 3 TRIUMPH-4 vs 22.5% for tirzepatide in SURMOUNT-1 and 15.8% for semaglutide in STEP-1)
Back Mojsov, S, Kopczynski, MG, Habener, JF (15 May 1990 )'Both amidated and nonamidated forms of glucagon-like peptide I are synthesized in the rat intestine and the pancreas', Journal of Biological Chemistry , 265/14, 8001-8
doi: 10.1038/nature09114 47
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